LDL

PCSK9

LDL RECEPTOR

PCSK9: It has LDL receptors in a serious bind

PCSK9: It has LDL receptors in a serious bind1

There are many factors to consider with regard to dyslipidemia.

Test your knowledge with some questions to start the conversation and see how your results compare with your fellow practitioners.

START
1/3
Approximately what percentage of your patients have high LDL-C levels?
< 25%
51% - 75%
26% - 50%
> 75%
SUBMIT
Here's the percentage of patients with high LDL-C levels seen by you and your peers:
REAL-TIME RESULTS
< 25%
40%
OF RESPONDENTS
51% - 75%
25%
OF RESPONDENTS
26% - 50%
25%
OF RESPONDENTS
> 75%
10%
OF RESPONDENTS
Among the 71 million American adults with high LDL-C levels, 37 million remain untreated, and 11 million who are treated continue to have uncontrolled LDL-C.4,*
WHO IS BURDENED?
NEXT QUESTION
2/3
What role does PCSK9 play in cholesterol metabolism?
Major role
No role at all
Minor role
Not sure
SUBMIT
What role does PCSK9 play in cholesterol metabolism? Here's how you and your peers answered:
REAL-TIME RESULTS
Major role
40%
OF RESPONDENTS
No role at all
25%
OF RESPONDENTS
Minor role
25%
OF RESPONDENTS
Not sure
10%
OF RESPONDENTS
Recent discoveries show that PCSK9 plays a critical role in the modulation of LDL-C levels.2
WHAT IS PCSK9?
NEXT QUESTION
3/3
PCSK9 physiologically impacts LDL-C levels by:
Increasing the number of LDLRs
Decreasing the number of LDLRs
SUBMIT
How does PCSK9 physiologically impact LDL-C levels? Here's how you and your peers answered:
REAL-TIME RESULTS
Increasing the number of LDLRs
50%
OF RESPONDENTS
Decreasing the number of LDLRs
50%
OF RESPONDENTS
By promoting LDLR degradation within hepatocytes, PCSK9 reduces the concentration of LDLRs on the hepatocyte surface, resulting in increased plasma LDL-C levels.5
PCSK9 & LDL-C

THE DYSLIPIDEMIA DILEMMA

What Is PCSK9?

PCSK9 is a protein that plays a critical role in the modulation of LDL-C levels.2

DISCOVER PCSK9
What Is PCSK9?

LDLR Recycling and LDL-C Levels

Recycling of LDLRs enables efficient clearance of plasma LDL particles.3

LDLR RECYCLING
LDLR Recycling and LDL-C Levels

Who Is Burdened by High Cholesterol?

Among the 71 million adult Americans with high LDL-C levels, 37 million remain untreated, and 11 million who are treated continue to have uncontrolled LDL-C.4,*

LEARN MORE
Who Is Burdened?

LDL = low-density lipoprotein; LDL-C = low-density lipoprotein cholesterol; LDLR = low-density lipoprotein receptor; PCSK9 = proprotein convertase subtilisin/kexin type 9; M = million.

*Based on the National Health and Nutrition Examination Survey (NHANES), 2005-2008.

LDL-C levels were examined using National Cholesterol Education Program’s Adult Treatment Panel III risk categories based on the risk for developing coronary heart disease in the next 10 years. High LDL-C was defined as ≥ 100 mg/dL for the high risk group, ≥ 130 mg/dL for the intermediate risk group, and ≥ 160 mg/dL for the low risk group or a person currently taking cholesterol-lowering medication.

References

  1. Lambert G, Sjouke B, Choque B, et al. J Lipid Res. 2012;53:2515-2524.
  2. Horton JD, Cohen JC, Hobbs HH. J Lipid Res. 2009;50(suppl):S172-S177.
  3. Goldstein JL, Brown MS. Arterioscler Thromb Vasc Biol. 2009;29:431-438.
  4. Centers for Disease Control and Prevention. MMWR. 2011;60:109-114.
  5. Qian Y-W, Schmidt RJ, Zhang Y, et al. J Lipid Res. 2007;48:1488-1498.