PCSK9: A recent discovery in understanding cholesterol regulation
Each year, our continued research deepens our understanding of PCSK9 biology and the critical role it plays in cholesterol metabolism.1
PCSK9, LDLRs, and LDL
PCSK9 regulates the recycling of LDLRs by targeting the LDLR for degradation2
PCSK9 is a protein that plays a critical role in the modulation of plasma LDL-C levels. HMG-CoA reductase plays a critical role in cholesterol biosynthesis. Both play a key role in cholesterol homeostasis.1,3 By promoting LDLR degradation within hepatocytes, PCSK9 reduces the concentration of LDLRs on the hepatocyte surface, resulting in increased plasma LDL-C levels.2
HMG-CoA = 3-hydroxy-3-methylglutaryl coenzyme A; LDL = low-density lipoprotein; LDL-C = low-density lipoprotein cholesterol; LDLR = low-density lipoprotein receptor; PCSK9 = proprotein convertase subtilisin/kexin type 9.
- Horton JD, Cohen JC, Hobbs HH. J Lipid Res. 2009;50(suppl):S172-S177.
- Qian Y-W, Schmidt RJ, Zhang Y, et al. J Lipid Res. 2007;48:1488-1498.
- Brown MS, Goldstein JL. Science. 1986;232:34-47.