What is PCSK9?

PCSK9: A recent discovery in understanding cholesterol regulation

Each year, our continued research deepens our understanding of PCSK9 biology and the critical role it plays in cholesterol metabolism.1

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The Role of PCSK9

Watch this video to see how PCSK9 impacts LDLRs and cholesterol metabolism

PCSK9, LDLRs, and LDL

PCSK9 DegradationPCSK9 Degradation

PCSK9 regulates the recycling of LDLRs by targeting the LDLR for degradation2

PCSK9 is a protein that plays a critical role in the modulation of plasma LDL-C levels. HMG-CoA reductase plays a critical role in cholesterol biosynthesis. Both play a key role in cholesterol homeostasis.1,3 By promoting LDLR degradation within hepatocytes, PCSK9 reduces the concentration of LDLRs on the hepatocyte surface, resulting in increased plasma LDL-C levels.2

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Take an in-depth look at PCSK9

Take an in-depth look at PCSK9

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What can we learn from PCSK9 mutations?

PCSK9 MUTATIONS

HMG-CoA = 3-hydroxy-3-methylglutaryl coenzyme A; LDL = low-density lipoprotein; LDL-C = low-density lipoprotein cholesterol; LDLR = low-density lipoprotein receptor; PCSK9 = proprotein convertase subtilisin/kexin type 9.

References

  1. Horton JD, Cohen JC, Hobbs HH. J Lipid Res. 2009;50(suppl):S172-S177.
  2. Qian Y-W, Schmidt RJ, Zhang Y, et al. J Lipid Res. 2007;48:1488-1498.
  3. Brown MS, Goldstein JL. Science. 1986;232:34-47.