Who is Burdened by High Cholesterol?
An estimated 48 million American adults with high LDL-C are not treated or not at goal1
Prevalence, treatment, and control of high levels of LDL-C based on NHANES 2005-20081,*
*Extrapolated from data that include 3,996 adults aged ≥ 20 years in NHANES 2005-2008.
†High LDL-C defined as ≥ 160 mg/dL for low-risk adults; ≥ 130 mg/dL for moderate-risk adults; and ≥ 100 mg/dL for high-risk adults or the use of cholesterol-lowering medication.
‡ATP III LDL-C goals: < 160 mg/dL for low-risk adults; < 130 mg/dL for moderate-risk adults; and < 100 mg/dL for high-risk adults.
Multiple factors contribute to increased CV risk4-7
Although some risk factors (eg, age, sex, family history) cannot be changed, many can be addressed through therapeutic interventions. These include high blood pressure, obesity, smoking, dietary habits, and lipid disorders such as elevated levels of triglycerides or LDL-C.4-6 However, the ability to produce sustainable changes in these modifiable risk factors continues to be challenging.
The Burden of CVD
According to the World Health Organization, CVD (ischemic heart disease and stroke) is the leading cause of death worldwide, responsible for 25.1% of deaths globally (14.1 million people) in 2012,8,* greater than all cancers combined.9,†
Why are so many adults unable to further lower their LDL-C levels despite treatment?LEARN WHY
AIDS = acquired immunodeficiency syndrome; ATP = Adult Treatment Panel; COPD = chronic obstructive pulmonary disease; CRP = C-reactive protein; CV = cardiovascular; CVD = cardiovascular disease; HDL = high-density lipoprotein; HIV = human immunodeficiency virus; LDL = low-density lipoprotein; LDL-C = low-density lipoprotein cholesterol; NHANES = National Health and Nutrition Examination Survey; TG = triglyceride.
*Data from worldwide values 2012 updated May 2014.
- Centers for Disease Control and Prevention. MMWR. 2011;60:109-114.
- Roger VL, Go AS, Lloyd-Jones DM, et al. Circulation. 2012;125:e2-e220.
- Heidenreich PA, Trogdon JG, Khavjou OA, et al. Circulation. 2011;123:933-944.
- Brunzell JD, Davidson M, Furberg CD, et al. J Am Coll Cardiol. 2008;51:1512-1524.
- Libby P. J Am Coll Cardiol. 2005;46:1225-1228.
- National Cholesterol Education Program. Circulation. 2002;106:3143-3421.
- Abifadel M, et al. In: Toth PP. The Year in Lipid Disorders. Vol. 2. Oxford, UK: Atlas Medical Publishing Ltd. 2010:3-23.
- World Health Organization. Top 10 causes of death. www.who.int/mediacentre/factsheets/fs310/en/index.html. Accessed December 2, 2014.
- World Health Organization. Cancer mortality and morbidity. http://www.who.int/gho/ncd/mortality_morbidity/cancer/en/. Accessed December 2, 2014.